Abstract
We describe a patient with severe and progressive encephalitis of unknown etiology. We performed rapid metagenomic sequencing from cerebrospinal fluid and identified Powassan virus, an emerging tick-borne flavivirus that has been increasingly detected in the United States.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Encephalitis Viruses, Tick-Borne / isolation & purification*
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Encephalitis, Tick-Borne / diagnosis*
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Encephalitis, Tick-Borne / therapy
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Encephalitis, Tick-Borne / virology*
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Genome, Viral
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Humans
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Immunoglobulins, Intravenous / administration & dosage
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Immunoglobulins, Intravenous / therapeutic use
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Immunologic Factors / administration & dosage
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Immunologic Factors / therapeutic use
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Male
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Metagenomics / methods*
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Middle Aged
Substances
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Immunoglobulins, Intravenous
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Immunologic Factors