The Role of Phylogenetics as a Tool to Predict the Spread of Resistance

J Infect Dis. 2017 Dec 1;216(suppl_9):S820-S823. doi: 10.1093/infdis/jix411.

Abstract

Drug resistance mutations emerge in genetic sequences of HIV through drug-selective pressure. Drug resistance can be transmitted. In this review we discuss phylogenetic methods used to study the emergence of drug resistance and the spread of resistant viruses.

Keywords: HIV; drug resistance; phylogenetics.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-HIV Agents / therapeutic use*
  • Drug Resistance, Viral / genetics
  • HIV / drug effects
  • HIV / genetics*
  • HIV Infections / drug therapy
  • HIV Infections / epidemiology*
  • HIV Infections / virology
  • Humans
  • Mutation / genetics
  • Phylogeny

Substances

  • Anti-HIV Agents