Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Affiliations

• ¹ Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK. [email protected].
• ² Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
• ³ Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, Scotland.
• ⁴ Estonian Genome Center, University of Tartu, University of Tartu, Tartu, 51010, Estonia.
• ⁵ Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
• ⁶ Institute of Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, 8036, Austria.
• ⁷ Institute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, 80131, Italy.
• ⁸ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
• ⁹ Department of Medical Sciences, University of Trieste, Trieste, 34100, Italy.
• ¹⁰ Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, 34137, Italy.
• ¹¹ Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.
• ¹² Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
• ¹³ Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Mental Health Services Copenhagen, Roskilde, DK-4000, Denmark.
• ¹⁴ iPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, DK-8000, Denmark.
• ¹⁵ QIMR Berghofer Institute of Medical Research, Brisbane, QLD, 4006, Australia.
• ¹⁶ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, 02215, USA.
• ¹⁷ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.
• ¹⁸ Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit, Amsterdam, Amsterdam Public Health Institute (APH), Amsterdam, 1081BT, Netherlands.
• ¹⁹ Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48109, USA.
• ²⁰ Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
• ²¹ Department of Epidemiology, Erasmus University Medical Center, Rotterdam, 3015 CN, Netherlands.
• ²² Cardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, 98101, USA.
• ²³ Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
• ²⁴ Department of Cardiology, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
• ²⁵ Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, 80045, USA.
• ²⁶ Department of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.
• ²⁷ Department for Health Evidence, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, 6500 HB, The Netherlands.
• ²⁸ MRC Unit for Lifelong Health & Ageing at UCL, University College London, London, WC1B 5JU, UK.
• ²⁹ Department of Medicine, GeneSTAR Research Program, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
• ³⁰ Centre for Epidemiology, Division of Population Health, Health Services Research & Primary Care, The University of Manchester, Manchester, Greater, Manchester, M13 9PL, UK.
• ³¹ Center for Biomedicine, European Academy of Bozen/Bolzano (EURAC), (Affiliated Institute of the University of Lübeck, Lübeck, Germany), Bolzano, 39100, Italy.
• ³² Institute of Genetic and Biomedical Research - Support Unity, National Research Council of Italy, Sassari, 07100, Italy.
• ³³ Institute of Molecular Genetics, National Research Council of Italy, Pavia, 27100, Italy.
• ³⁴ Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore City, MD, 21224, USA.
• ³⁵ Department of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
• ³⁶ Health Science Center at Houston, UTHealth School of Public Health, University of Texas, Houston, TX, 77030, USA.
• ³⁷ Department of Biomedicine-Human Genetics, Aarhus University, DK-8000, Aarhus C, Denmark.
• ³⁸ Centre for Integrative Sequencing, iSEQ, Aarhus University, DK-8000, Aarhus C, Denmark.
• ³⁹ Centre for Genomic & Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.
• ⁴⁰ Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55454, USA.
• ⁴¹ Charité Research Group on Geriatrics, Charité, Universitätsmedizin Berlin, Berlin, 13347, Germany.
• ⁴² Lipid Clinic at the Interdisciplinary Metabolism Center, Charité, Universitätsmedizin Berlin, Berlin, 13353, Germany.
• ⁴³ Institute for Medical and Human Genetics, Charité, Universitätsmedizin Berlin, Berlin, 13353, Germany.
• ⁴⁴ Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, 48014, USA.
• ⁴⁵ Robertson Center for biostatistics, University of Glasgow, Glasgow, G12 8QQ, UK.
• ⁴⁶ IRCCS Neuromed, Pozzilli (IS), 86077, Italy.
• ⁴⁷ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, 27514, USA.
• ⁴⁸ Institute of Cardiovascular Science, University College London, London, WC1E 6BT, UK.
• ⁴⁹ Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, 2300, Denmark.
• ⁵⁰ Department of Microbiology and Immunology, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
• ⁵¹ Gerontology Research Center, Tampere, Finland, Faculty of Social Sciences, University of Tampere, Tampere, 33104, Finland.
• ⁵² Genetic and Molecular Epidemiology Group, Institute of Neurogenetics, University of Lübeck, 23562, Lübeck, Germany.
• ⁵³ Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, 14195, Germany.
• ⁵⁴ Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Berlin, 14195, Germany.
• ⁵⁵ Department of Statistics, University of Auckland, Auckland, 1010, New Zealand.
• ⁵⁶ Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.
• ⁵⁷ Division of Population Health, Health Services Research & Primary Care, School of Health Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, M13 9PL, UK.
• ⁵⁸ TH Chan School of Public Health, Harvard Medical School, Boston, MA, 02115, USA.
• ⁵⁹ Austrian Stroke Prevention Study, Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
• ⁶⁰ Section of Molecular Epidemiology, Department of medical statistics, Leiden University Medical Center, Leiden, 2300RC, The Netherlands.
• ⁶¹ Division of Population Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK.
• ⁶² Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, 98101, USA.
• ⁶³ NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, 0450, Norway.
• ⁶⁴ Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, 23562, Germany.
• ⁶⁵ Neuroepidemiology and Ageing Research Group, School of Public Health, Imperial College, London, W6 8RP, UK.
• ⁶⁶ Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, Greater Manchester, M13 9PL, UK.
• ⁶⁷ Cardiovascular Health Research Unit, Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, 98101, USA.
• ⁶⁸ Kaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.
• ⁶⁹ Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
• ⁷⁰ BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, G12 8TD, UK.
• ⁷¹ Program in Medical and Population Genetics, Broad Institute, Broad Institute, Cambridge, MA, 02142, USA.