Abstract
Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future.
Keywords:
COX-2; Corydaline; MAPK; enterovirus 71.
MeSH terms
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Antiviral Agents / pharmacology*
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Berberine Alkaloids / pharmacology*
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Cyclooxygenase 2 Inhibitors / pharmacology*
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Enterovirus A, Human / drug effects*
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Humans
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JNK Mitogen-Activated Protein Kinases / drug effects
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JNK Mitogen-Activated Protein Kinases / metabolism
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Molecular Structure
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Piperidines / pharmacology
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Pyridazines / pharmacology
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Signal Transduction / drug effects
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Virus Replication / drug effects*
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p38 Mitogen-Activated Protein Kinases / drug effects
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p38 Mitogen-Activated Protein Kinases / metabolism
Substances
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Antiviral Agents
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Berberine Alkaloids
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Cyclooxygenase 2 Inhibitors
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Piperidines
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Pyridazines
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corydaline
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pirodavir
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JNK Mitogen-Activated Protein Kinases
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p38 Mitogen-Activated Protein Kinases