Abstract
Multifunctional low-generation dendrimer-entrapped gold nanoparticles (Au DENPs) were designed and synthesized. The formed Au DENPs modified with an arginine-glycine-aspartic peptide and labeled with 99mTc possess a uniform size distribution, desirable colloidal stability and biocompatibility, and can be used as a promising nanoprobe for targeted SPECT/CT imaging of αvβ3 integrin-expressing tumors.
MeSH terms
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Cell Line, Tumor
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Contrast Media / chemistry
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Contrast Media / therapeutic use
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Dendrimers / chemistry
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Dendrimers / therapeutic use*
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Gene Expression Regulation, Neoplastic
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Gold / chemistry
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Humans
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Integrin alpha5 / genetics
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Integrin beta3 / genetics
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Metal Nanoparticles / chemistry
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Metal Nanoparticles / therapeutic use*
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Neoplasms / diagnostic imaging*
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Neoplasms / drug therapy
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Neoplasms / genetics
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Neoplasms / pathology
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Pathology, Molecular
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Peptides / chemistry
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Peptides / therapeutic use*
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Single Photon Emission Computed Tomography Computed Tomography
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Technetium / therapeutic use
Substances
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Contrast Media
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Dendrimers
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Integrin alpha5
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Integrin beta3
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Peptides
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Technetium
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Gold