Hemodynamic Changes on Cone-Beam Computed Tomography during Balloon-Occluded Transcatheter Arterial Chemoembolization Using Miriplatin for Hepatocellular Carcinoma: A Preliminary Study

Dig Dis. 2017;35(6):598-601. doi: 10.1159/000480255. Epub 2017 Oct 17.

Abstract

Background/aim: Balloon-occluded transcatheter arterial chemoembolization (B-TACE) using miriplatin (MPT) is anticipated as a new strategy for hepatocellular carcinoma (HCC). This study was aimed at evaluating the hemodynamic changes with/without balloon occlusion of the hepatic artery, correlation of cone-beam CT (CBCT) pixels, and CT value after B-TACE for HCC.

Methods: A total of 52 patients with HCC, who underwent B-TACE using MPT in addition to the balloon-occluded CBCT hepatic arteriography, were studied.

Results: After balloon occlusion, CBCT pixel values increased in 37 lesions, whereas it decreased in 15 lesions. Intratumoral CT values after B-TACE were lower with decreased CBCT pixel values than with increased CBCT pixel values.

Conclusion: Hemodynamic changes on CBCT during balloon occlusion can be used to predict the efficacy of B-TACE using MPT.

Keywords: Balloon-occluded transcatheter arterial chemoembolization; CT value; Cone-beam CT; Miriplatin; Pixel.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Balloon Occlusion*
  • Carcinoma, Hepatocellular / diagnostic imaging*
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / pathology
  • Carcinoma, Hepatocellular / physiopathology
  • Chemoembolization, Therapeutic / methods*
  • Cone-Beam Computed Tomography / methods*
  • Female
  • Hemodynamics*
  • Hepatic Artery / pathology
  • Humans
  • Liver Neoplasms / diagnostic imaging*
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / pathology
  • Liver Neoplasms / physiopathology
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Organoplatinum Compounds / therapeutic use*
  • Survival Analysis
  • Treatment Outcome

Substances

  • Organoplatinum Compounds
  • miriplatin