cGAS Micro-Manages Genotoxic Stress

Mona Motwani; Katherine A Fitzgerald

doi:10.1016/j.immuni.2017.09.020

cGAS Micro-Manages Genotoxic Stress

Immunity. 2017 Oct 17;47(4):616-617. doi: 10.1016/j.immuni.2017.09.020.

Authors

Mona Motwani¹, Katherine A Fitzgerald²

Affiliations

¹ Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Program in Innate Immunity, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: [email protected].

PMID: 29045895
DOI: 10.1016/j.immuni.2017.09.020

Abstract

Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive type I IFN responses.

Publication types

Comment

MeSH terms

Cell Nucleus
Cytosol
DNA
DNA Damage*
Nucleotidyltransferases / genetics*

Substances

DNA
Nucleotidyltransferases