Streptococci target inflammasome

Nat Microbiol. 2017 Oct;2(10):1334-1335. doi: 10.1038/s41564-017-0031-4.

Abstract

The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

Publication types

  • Comment

MeSH terms

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Carrier Proteins*
  • Inflammasomes*
  • NLR Family, Pyrin Domain-Containing 3 Protein

Substances

  • Antigens, Bacterial
  • Bacterial Outer Membrane Proteins
  • Carrier Proteins
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • streptococcal M protein