Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

J Dermatol. 2018 Feb;45(2):211-215. doi: 10.1111/1346-8138.14106. Epub 2017 Oct 23.

Abstract

Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47-year-old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2-year history of vitiligo and long-term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Interestingly, prurigo nodularis (PN) was found in histopathology at 1-year follow up. To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN.

Keywords: generalized; keratoacanthoma; oral lesions; prurigo nodularis; vitiligo.

Publication types

  • Review

MeSH terms

  • Anti-Allergic Agents / therapeutic use
  • Biopsy
  • Humans
  • Keratoacanthoma / complications*
  • Keratoacanthoma / diagnosis
  • Keratoacanthoma / drug therapy
  • Keratoacanthoma / pathology
  • Keratolytic Agents / therapeutic use
  • Male
  • Middle Aged
  • Mouth Mucosa / pathology
  • Plant Extracts / therapeutic use
  • Prurigo / complications*
  • Prurigo / diagnosis
  • Prurigo / drug therapy
  • Prurigo / pathology
  • Skin / pathology
  • Treatment Outcome
  • Tripterygium / chemistry
  • Vitiligo / diagnosis
  • Vitiligo / etiology*
  • Vitiligo / pathology

Substances

  • Anti-Allergic Agents
  • Keratolytic Agents
  • Plant Extracts