Elevated serum adenosine deaminase levels in neuroleptic-naïve patients with recent-onset schizophrenia

Arun Sasidharan; Sunil Kumar; John P John; Mariamma Philip; Sarada Subramanian; Sanjeev Jain; Bindu M Kutty

doi:10.1016/j.ajp.2017.03.034

Elevated serum adenosine deaminase levels in neuroleptic-naïve patients with recent-onset schizophrenia

Asian J Psychiatr. 2017 Oct:29:13-15. doi: 10.1016/j.ajp.2017.03.034. Epub 2017 Mar 27.

Authors

Arun Sasidharan¹, Sunil Kumar², John P John³, Mariamma Philip⁴, Sarada Subramanian⁵, Sanjeev Jain⁶, Bindu M Kutty⁷

Affiliations

¹ Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India; Multimodal Brain Image Analysis Laboratory (MBIAL), National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
² Multimodal Brain Image Analysis Laboratory (MBIAL), National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
³ Multimodal Brain Image Analysis Laboratory (MBIAL), National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India; Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India; Department of Clinical Neuroscience, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India. Electronic address: [email protected].
⁴ Department of Biostatistics, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
⁵ Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
⁶ Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India; Molecular Genetics Laboratory, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.
⁷ Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru, India.

PMID: 29061410
DOI: 10.1016/j.ajp.2017.03.034

Abstract

The present study examined serum levels of adenosine deaminase (ADA), an adenosine metabolizing enzyme, in neuroleptic-naive patients with recent-onset schizophrenia and age-matched healthy comparison subjects. ADA levels were found to be higher among patients, and revealed a possible link between evening rise and severity of auditory hallucinations as well as morning rise and severity of avolition-apathy in patients with schizophrenia. These findings suggest the potential utility of serum ADA as a peripheral biomarker of schizophrenia.

Keywords: Adenosine deaminase; Avolition; Hallucination; Neuroleptic-naive; Schizophrenia.

MeSH terms

Adenosine Deaminase / blood*
Adolescent
Adult
Biomarkers / blood
Female
Hallucinations / blood*
Hallucinations / diagnosis
Humans
Male
Schizophrenia / blood*
Schizophrenia / diagnosis
Severity of Illness Index
Young Adult

Substances

Biomarkers
Adenosine Deaminase