PLD and PA Take MT1-MMP for a Metastatic Ride

Narendra Thapa; Richard A Anderson

doi:10.1016/j.devcel.2017.10.012

PLD and PA Take MT1-MMP for a Metastatic Ride

Dev Cell. 2017 Oct 23;43(2):117-119. doi: 10.1016/j.devcel.2017.10.012.

Authors

Narendra Thapa¹, Richard A Anderson²

Affiliations

¹ University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA.
² University of Wisconsin-Madison, School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA. Electronic address: [email protected].

Abstract

Polarized targeting and deposition of MT1-MMP is pivotal for metastasis. In this issue of Developmental Cell, Wang et al. (2017) reveal that a signaling molecule generated by phospholipase D2 drives deposition of MT1-MMP at the site of invadopodia formation and is critical for metastasis in a transgenic breast cancer model.

Publication types

Comment

MeSH terms

Animals
Breast Neoplasms*
Cell Line, Tumor
Matrix Metalloproteinase 14*
Mice
Phosphatidic Acids

Substances

Matrix Metalloproteinase 14
Phosphatidic Acids

Abstract

Publication types

MeSH terms

Substances

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