The contractile and diastolic function of smooth muscle cells (SMCs) is closely related to penile erection and erectile dysfunction (ED). In addition to nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), sulfur dioxide (SO2), estrogen receptor (ER), P2Y receptor, perivascular tissue (PVT), and calcium activated potassium channel (Kca) are found to be involved in the relaxation of SMCs. This review updates the mechanisms of the relaxation of SMCs and its relationship with ED.
平滑肌细胞（SMC）的收缩和舒张功能与勃起及勃起功能障碍（ED）有密切关系。除了一氧化氮（NO）、一氧化碳（CO）、硫化氢（H2S）外，目前发现二氧化硫（SO2）、雌激素受体（ER）、P2Y受体、血管外周围组织（PVT）、钙离子激活钾通道（Kca）等都参与了SMC舒张。本文就近年来SMC舒张机制方面的新进展及与ED的关系予以综述。.
Keywords: P2Y receptor; calcium activated potassium channel; erectile dysfunction; perivascular tissue; relaxation; estrogen receptor; smooth muscle cell; sulfur dioxide.