Stress disease is a body functional disorder caused by harmful stimuli overwhelming the nonspecific adaptive capabilities. Numerous evidence proved the feasibility of acupuncture in treating stress diseases. This paper aims at exploring new perspective in the study on the underlying mechanism of acupuncture in the treatment of stress diseases. The discussion is conducted by summarizing the pathogenesis of stress diseases and mechanisms of its treatment with acupuncture, in exploring the related factors of acupuncture and stress response, and the correlation between the two from the regulatory pathway, medium, characteristics and manifestations.