Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity

Shi-Li Yan; Yan-Hong Li; Xuan-Qin Chen; Dan Liu; Chin-Ho Chen; Rong-Tao Li

doi:10.1016/j.phytochem.2017.10.006

Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity

Phytochemistry. 2018 Jan:145:40-47. doi: 10.1016/j.phytochem.2017.10.006. Epub 2017 Nov 5.

Authors

Shi-Li Yan¹, Yan-Hong Li¹, Xuan-Qin Chen¹, Dan Liu¹, Chin-Ho Chen², Rong-Tao Li³

Affiliations

¹ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, PR China.
² Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC, USA. Electronic address: [email protected].
³ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, PR China. Electronic address: [email protected].

PMID: 29080411
DOI: 10.1016/j.phytochem.2017.10.006

Abstract

Six previously undescribed diterpenoids, named euphorantins S-T and euphorneroids A-D, including ingol and ent-atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent-3-oxoatisan-16α,17-acetonide exhibited moderate anti-HIV-1 activities, with EC₅₀ values of 34 μM (SI = 2.3) and 24 μM (SI = 1.9), respectively.

Keywords: Anti-HIV activity; Euphorantins S-T; Euphorbia neriifolia; Euphorbiaceae; Euphorneroids A-D.

MeSH terms

Anti-HIV Agents / chemistry
Anti-HIV Agents / isolation & purification
Anti-HIV Agents / pharmacology*
Cell Line
Diterpenes / chemistry
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Dose-Response Relationship, Drug
Euphorbia / chemistry*
HIV-1 / drug effects*
Humans
Microbial Sensitivity Tests
Molecular Structure
Plant Bark / chemistry*
Plant Stems / chemistry*
Structure-Activity Relationship

Substances

Anti-HIV Agents
Diterpenes