Genome editing technology, as an innovative biotechnology, has been widely used for editing the genome from model organisms, animals, plants and microbes. CRISPR/Cas9-based genome editing technology shows its great value and potential in the dissection of functional genomics, improved breeding and genetic disease treatment. In the present special issue, the principle and application of genome editing techniques has been summarized. The advantages and disadvantages of the current genome editing technology and future prospects would also be highlighted.
基因组编辑技术，作为一项生物医学领域的革新技术，已经在动物、植物和微生物基因组改造中得到了广泛的应用。以CRISPR/Cas9 为主导的基因组编辑技术掀起了基因组编辑的浪潮，在功能基因组学、遗传改良育种、遗传病治疗等研究中展示出其极大的价值与潜力。本专刊报道了基因组编辑技术的总体状况、在相关领域的基础与应用研究、该技术当前存在的优缺点以及未来展望等。.
Keywords: CRISPR/Cas9; genome editing; progress.