Amycolamycins A and B, Two Enediyne-Derived Compounds from a Locust-Associated Actinomycete

Org Lett. 2017 Nov 17;19(22):6208-6211. doi: 10.1021/acs.orglett.7b03113. Epub 2017 Nov 1.

Abstract

Two novel enediyne-derived natural products, amycolamycins A and B (1 and 2), were characterized from a locust-associated actinomycete Amycolatopsis sp. HCa4. Amycolamycins A and B contain a unique 2-(cyclopenta[a]inden-5-yl)oxirane core with suspected enediyne polyketide biosynthetic origin. Sequencing and analysis of the acm biosynthetic gene cluster allowed us to propose the biosynthetic pathway of 1 and 2. Moreover, amycolamycin A (1) was selectively cytotoxic to the M231 breast cancer cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinobacteria*
  • Animals
  • Enediynes
  • Glucosides
  • Grasshoppers
  • Molecular Structure
  • Multigene Family
  • Pyrroles

Substances

  • Enediynes
  • Glucosides
  • Pyrroles
  • amycolamicin