Abstract
Following the observation of antitumor activity for the combination of 5-fluorouracil (5-FU) and cisplatin in metastatic colorectal carcinoma, the combination of 5-FU and iproplatin was tested, also in colorectal carcinoma, in the hope of attaining equivalent activity without the nephrotoxicity observed with 5-FU/cisplatin. However, no responses were achieved with 5-FU/iproplatin.
MeSH terms
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Adult
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Aged
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma / drug therapy*
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Colorectal Neoplasms / drug therapy*
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Drug Evaluation
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Female
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Fluorouracil / administration & dosage*
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Humans
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Male
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Middle Aged
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Organoplatinum Compounds / administration & dosage*
Substances
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Antineoplastic Agents
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Organoplatinum Compounds
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iproplatin
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Fluorouracil