Neuronal activity in the glioma microenvironment

Tessa Johung; Michelle Monje

doi:10.1016/j.conb.2017.10.009

Neuronal activity in the glioma microenvironment

Curr Opin Neurobiol. 2017 Dec:47:156-161. doi: 10.1016/j.conb.2017.10.009. Epub 2017 Nov 6.

Authors

Tessa Johung¹, Michelle Monje²

Affiliations

¹ Department of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, USA.
² Departments of Neurology, Pediatrics, and Pathology, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA. Electronic address: [email protected].

Abstract

Gliomas are the most common primary brain tumor and high-grade gliomas the leading cause of brain tumor-related death in both children and adults. An appreciation for the crucial role of the nervous system in the tumor microenvironment is emerging for cancers in general, and the neural regulation of glioma progression has come into sharp focus. Here, we review what is known about the influence of active neurons on glioma pathobiology.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Neoplasms / physiopathology*
Glioma / physiopathology*
Humans
Neurons / pathology*
Neurons / physiology
Tumor Microenvironment / physiology*

Grants and funding

R01 NS092597/NS/NINDS NIH HHS/United States