PIP-ing Lipids on Membranes: PTEN Takes the Cake

Archna Ravi; Brooke M Emerling

doi:10.1016/j.molcel.2017.10.026

PIP-ing Lipids on Membranes: PTEN Takes the Cake

Mol Cell. 2017 Nov 2;68(3):471-472. doi: 10.1016/j.molcel.2017.10.026.

Authors

Archna Ravi¹, Brooke M Emerling²

Affiliations

¹ Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
² Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 29100049
DOI: 10.1016/j.molcel.2017.10.026

Abstract

In this issue of Molecular Cell, Malek et al. (2017) describe a novel HPLC-MS method permitting separation of PI(3,4)P₂ and PI(4,5)P₂, a technical issue hindering the phosphoinositide signaling field. They use this method to uncover a new target and critical role for PTEN in cancer.

Published by Elsevier Inc.

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MeSH terms

Humans
Neoplasms*
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases*
Phosphatidylinositols
Signal Transduction

Substances

Phosphatidylinositols
phosphoinositide-3,4-bisphosphate
Phosphatidylinositol 3-Kinases
PTEN Phosphohydrolase
PTEN protein, human