Astrocytes Supply Presynaptic Terminals with a Sweet Incentive to Make Connections

Giuseppe Condomitti; Joris de Wit

doi:10.1016/j.devcel.2017.10.018

Astrocytes Supply Presynaptic Terminals with a Sweet Incentive to Make Connections

Dev Cell. 2017 Nov 6;43(3):261-263. doi: 10.1016/j.devcel.2017.10.018.

Authors

Giuseppe Condomitti¹, Joris de Wit²

Affiliations

¹ VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Herestraat 49, 3000 Leuven, Belgium.
² VIB Center for Brain & Disease Research, Herestraat 49, 3000 Leuven, Belgium; KU Leuven, Department of Neurosciences, Herestraat 49, 3000 Leuven, Belgium. Electronic address: [email protected].

PMID: 29112849
DOI: 10.1016/j.devcel.2017.10.018

Abstract

Glial cells shape neural circuits by secreting cues that contribute to the spatiotemporal control of connectivity. A new study in Neuron from Farhy-Tselnicker et al. (2017) shows that the astrocyte-secreted heparan sulfate proteoglycan GPC4 acts on presynaptic terminals to indirectly regulate AMPA receptor clustering and active synapse formation.

Publication types

Review
Comment

MeSH terms

Animals
Astrocytes / metabolism*
Hippocampus / metabolism*
Humans
Motivation / physiology*
Neurons / metabolism
Presynaptic Terminals / metabolism*
Synapses / metabolism*

Grants and funding

MC_UP_1201/15/MRC_/Medical Research Council/United Kingdom