Management, outcomes, and prognostic factors of ruptured hepatocellular carcinoma: A systematic review

J Surg Oncol. 2018 Mar;117(3):341-353. doi: 10.1002/jso.24869. Epub 2017 Nov 8.

Abstract

Ruptured hepatocellular (rHCC) is a rare but life-threatening presentation that often requires acute intervention. In this systematic review we identified 67 eligible studies reporting on 4941 patients with rHCC. Here we present the treatment approaches for the management of rHCC both in the acute setting with regards to management of hemorrhage, as well long-term with regards to oncological treatment.

Keywords: hepatocellular carcinoma; management; rupture; survival; systematic review.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Ablation Techniques
  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / surgery
  • Carcinoma, Hepatocellular / therapy*
  • Chemoembolization, Therapeutic
  • Female
  • Hepatectomy
  • Humans
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / surgery
  • Liver Neoplasms / therapy*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Rupture, Spontaneous
  • Treatment Outcome