Development of a high-performance, enterprise-level, multimode LC-MS/MS autosampler for drug discovery

Bioanalysis. 2017 Nov;9(21):1643-1654. doi: 10.4155/bio-2017-0149. Epub 2017 Nov 9.
No abstract available

Keywords: ADME; Cassette analysis; LC–MS/MS; high-throughput; peak capacity.

MeSH terms

  • Amines / analysis
  • Amines / metabolism
  • Chromatography, High Pressure Liquid / instrumentation
  • Chromatography, High Pressure Liquid / methods*
  • Cyclohexanecarboxylic Acids / analysis
  • Cyclohexanecarboxylic Acids / metabolism
  • Drug Discovery
  • Gabapentin
  • Humans
  • Microsomes, Liver / metabolism
  • Pharmaceutical Preparations / analysis*
  • Pharmaceutical Preparations / metabolism
  • Tandem Mass Spectrometry / instrumentation
  • Tandem Mass Spectrometry / methods*
  • gamma-Aminobutyric Acid / analysis
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Amines
  • Cyclohexanecarboxylic Acids
  • Pharmaceutical Preparations
  • gamma-Aminobutyric Acid
  • Gabapentin