Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis in Liver Transplantation

Clin Liver Dis. 2018 Feb;22(1):213-227. doi: 10.1016/j.cld.2017.08.015. Epub 2017 Oct 6.

Abstract

The number of transplants caused by nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NASH) has been progressively increasing and this is expected to become the most common indication for liver transplant in the United States. Patients with NASH show many features of the metabolic syndrome and, as a result, are at higher risk for postoperative cardiovascular morbidity and mortality. Despite this, patients with NASH have long-term graft and patient survival rates comparable with other causes of chronic liver disease. Posttransplant metabolic syndrome is a common occurrence that increases the risk of steatosis in the graft liver.

Keywords: Liver transplant; Metabolic syndrome; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Recurrent NAFLD.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / complications
  • Diabetes Complications / complications
  • Humans
  • Kidney Diseases / complications
  • Lipase / genetics
  • Liver Transplantation* / adverse effects
  • Membrane Proteins / genetics
  • Metabolic Syndrome / etiology
  • Mutation
  • Non-alcoholic Fatty Liver Disease / complications
  • Non-alcoholic Fatty Liver Disease / genetics
  • Non-alcoholic Fatty Liver Disease / surgery*
  • Obesity / complications*
  • Postoperative Complications / etiology
  • Preoperative Period

Substances

  • Membrane Proteins
  • Lipase
  • adiponutrin, human