Birth, coming of age and death: The intriguing life of long noncoding RNAs

Samudyata; Gonçalo Castelo-Branco; Alessandro Bonetti

doi:10.1016/j.semcdb.2017.11.012

Birth, coming of age and death: The intriguing life of long noncoding RNAs

Semin Cell Dev Biol. 2018 Jul:79:143-152. doi: 10.1016/j.semcdb.2017.11.012. Epub 2017 Nov 20.

Authors

Samudyata¹, Gonçalo Castelo-Branco¹, Alessandro Bonetti²

Affiliations

¹ Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.
² Laboratory of Molecular Neurobiology, Department Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Division of Genomic Technologies, RIKEN Center for Life Science Technologies, RIKEN Yokohama, Japan. Electronic address: [email protected].

PMID: 29133230
DOI: 10.1016/j.semcdb.2017.11.012

Abstract

Mammalian genomes are pervasively transcribed, with long noncoding RNAs being the most abundant fraction. Recent studies have highlighted the central role played by these transcripts in several physiological and pathological processes. Despite several metabolic features shared between coding and noncoding transcripts, these two classes of RNAs exhibit multiple differences regarding their biogenesis and processing. Here we review such distinctions, focusing on the unique features of specific long noncoding RNAs.

Keywords: Polyadenylation; RNA processing; Splicing; Subcellular localization; Transcription; circRNA; eRNA; lncRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation
Genome / genetics*
Humans
Models, Genetic
RNA Precursors / genetics*
RNA Processing, Post-Transcriptional*
RNA Stability
RNA, Long Noncoding / genetics*
RNA, Long Noncoding / metabolism

Substances

RNA Precursors
RNA, Long Noncoding