SnapShot: Chronic Lymphocytic Leukemia

Elisa Ten Hacken; Romain Guièze; Catherine J Wu

doi:10.1016/j.ccell.2017.10.015

SnapShot: Chronic Lymphocytic Leukemia

Cancer Cell. 2017 Nov 13;32(5):716-716.e1. doi: 10.1016/j.ccell.2017.10.015.

Authors

Elisa Ten Hacken¹, Romain Guièze², Catherine J Wu³

Affiliations

¹ Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.
² CHU Clermont-Ferrand, Hématologie Clinique, Clermont-Ferrand, France.
³ Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Broad Institute, Cambridge, MA, USA.

Abstract

Despite the recent advances in the therapeutic management of Chronic Lymphocytic Leukemia (CLL) patients, this common B cell malignancy still remains incurable. This SnapShot provides an overview of CLL biology and therapy, with a focus on genetics and microenvironmental interactions, which contribute to disease progression and therapy resistance. To view this SnapShot, open or download the PDF.

MeSH terms

B-Lymphocytes / metabolism
B-Lymphocytes / pathology
Disease Progression
Genetic Predisposition to Disease / genetics*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Leukemia, Lymphocytic, Chronic, B-Cell / therapy
Models, Genetic
Mutation*
Signal Transduction / genetics
Tumor Microenvironment / genetics*

Abstract

MeSH terms

Grants and funding