To retrospectively analyze the prognostic significance of plasma Epstein-Barr virus (EBV) DNA in 122 patients with diffuse large B cell lymphoma (DLBCL). Plasma EBV DNA positivity was related to advanced disease stage (P=0.030), B symptoms (P=0.004) and elevated serum lactic dehydrogenase (LDH) (P=0.001). Furthermore, univariate analysis indicated that plasma EBV DNA level was associated with worse overall survival (OS) (HR=0.223, 95%CI 0.096-0.518, P<0.001) and worse progression free survival (PFS) (HR=4.417, 95%CI 1.911-10.208, P<0.001), whereas multivariate analysis showed plasma EBV DNA as a probable independent prognostic factor of clinical outcome(HR=0.409, 95%CI 0.166-1.008, P=0.052).
回顾性分析122例弥漫大B细胞淋巴瘤(DLBCL)临床资料，探讨血浆EB病毒(EBV)DNA阳性(≥1.0×10(3) copies/ml)与DLBCL预后的关系。结果显示，血浆EBV DNA阳性与Ann Arbor分期高(P＝0.030)、有B症状(P＝0.004)、LDH水平高(P＝0.001)相关。单因素分析显示，血浆EBV DNA阳性是影响DLBCL患者总体生存(HR＝0.223，95%CI 0.096～0.518, P<0.001)及无进展生存(HR＝4.417，95%CI 1.911～10.208, P<0.001)的预后因素；多因素分析显示，血浆EBV DNA可能是DLBCL总体生存的独立预后因素(HR＝0.409, 95%CI 0.166～1.008，P＝0.052)。.
Keywords: Diffuse large B-cell lymphoma; Epstein-Barr virus; Lymphoma; Prognosis.