Abstract
Chemotherapy is limited by its poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complex has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chelating Agents / chemical synthesis
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Chelating Agents / chemistry
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Chelating Agents / pharmacology*
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Coordination Complexes / chemical synthesis
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Imines / chemistry
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Imines / pharmacology*
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Ligands
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Models, Molecular
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Molecular Structure
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Pyridines / chemistry
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Pyridines / pharmacology*
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Ruthenium / chemistry
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Ruthenium / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Chelating Agents
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Coordination Complexes
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Imines
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Ligands
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Pyridines
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Ruthenium