A Synaptic Basis for GLP-1 Action in the Brain

Sandrine Lefort; Matthias H Tschöp; Cristina García-Cáceres

doi:10.1016/j.neuron.2017.10.034

A Synaptic Basis for GLP-1 Action in the Brain

Neuron. 2017 Nov 15;96(4):713-715. doi: 10.1016/j.neuron.2017.10.034.

Authors

Sandrine Lefort¹, Matthias H Tschöp¹, Cristina García-Cáceres²

Affiliations

¹ Helmholtz Diabetes Center and German Center for Diabetes Research (DZD), Helmholtz Zentrum München, München, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, München, Germany.
² Helmholtz Diabetes Center and German Center for Diabetes Research (DZD), Helmholtz Zentrum München, München, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, München, Germany. Electronic address: [email protected].

PMID: 29144968
DOI: 10.1016/j.neuron.2017.10.034

Abstract

Unraveling the brain control of metabolism may generate opportunities to discover novel precision medicines for obesity and diabetes. In this issue of Neuron, Liu et al. (2017) identify a novel glucagon-like peptide (GLP)-1 receptor-dependent signaling process that exerts anorexigenic action via the regulation of AMPA receptor subunit composition in the hypothalamus.

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MeSH terms

Brain
Glucagon-Like Peptide 1*
Glucagon-Like Peptide-1 Receptor
Hypothalamus
Receptors, AMPA*

Substances

Glucagon-Like Peptide-1 Receptor
Receptors, AMPA
Glucagon-Like Peptide 1