The suppression by moderate-level contralateral sound of auditory-nerve-fiber responses to ipsilateral stimuli at the characteristic frequency (CF) was studied in barbiturate-anesthetized cats. The dependence of suppression strength on ipsilateral and contralateral stimulus variables, including level, frequency, bandwidth, and timing relationships, was investigated. The principal findings were: (1) Contralateral-sound suppression is greatest when the ipsilateral stimulus level is within the dynamic range of the unit. (2) When the contralateral stimuli are tones, suppression is greatest when the contralateral tone frequency is at or near CF. (3) Units with CFs above 3-4 kHz are only weakly suppressed by contralateral CF tones but more strongly suppressed by contralateral broad-band noise. (4) Continuous contralateral stimuli are significantly more effective suppressors than are gated stimuli. The characteristics of contralateral-sound suppression are compared with the physiology and anatomy of the uncrossed medial olivocochlear efferents, the subset of efferents which are the primary mediators of the effect.