Poppers regulation for public sale: No measure in France yet

Caroline Victorri-Vigneau; David Trewick; Thomas Dejoie; Damien Masson; Samuel Bulteau; Morgane Rousselet; Anne Sauvaget; Marie Grall-Bronnec; Pascale Jolliet

doi:10.1016/j.therap.2017.09.002

Poppers regulation for public sale: No measure in France yet

Therapie. 2018 May-Jun;73(3):217-221. doi: 10.1016/j.therap.2017.09.002. Epub 2017 Oct 23.

Authors

Caroline Victorri-Vigneau¹, David Trewick², Thomas Dejoie³, Damien Masson³, Samuel Bulteau⁴, Morgane Rousselet⁵, Anne Sauvaget⁴, Marie Grall-Bronnec⁶, Pascale Jolliet⁷

Affiliations

¹ Pharmacology department, Nantes university hospital, Hôtel-Dieu, 9, quai Moncousu, 44093 Nantes cedex, France; Inserm U1246 Sphere "methodS in Patient-centered outcomes and HEalth ResEarch", Nantes university, institute of health research IRS, 44200 Nantes, France. Electronic address: [email protected].
² Emergency department, Nantes university hospital, Hôtel-Dieu, 9, quai Moncousu, 44093 Nantes cedex, France. Electronic address: [email protected].
³ Biochemistry department, Nantes university hospital, Hôtel-Dieu, 44093 Nantes cedex, France.
⁴ Psychiatry department, Nantes university hospital, Hôtel-Dieu, CAPPA-Jacques-Prevert, 44093 Nantes cedex 1, France.
⁵ Pharmacology department, Nantes university hospital, Hôtel-Dieu, 9, quai Moncousu, 44093 Nantes cedex, France; Inserm U1246 Sphere "methodS in Patient-centered outcomes and HEalth ResEarch", Nantes university, institute of health research IRS, 44200 Nantes, France; Addictology department, Nantes university hospital, hôpital Saint-Jacques, 44093 Nantes cedex 1, France.
⁶ Inserm U1246 Sphere "methodS in Patient-centered outcomes and HEalth ResEarch", Nantes university, institute of health research IRS, 44200 Nantes, France; Addictology department, Nantes university hospital, hôpital Saint-Jacques, 44093 Nantes cedex 1, France.
⁷ Pharmacology department, Nantes university hospital, Hôtel-Dieu, 9, quai Moncousu, 44093 Nantes cedex, France; Inserm U1246 Sphere "methodS in Patient-centered outcomes and HEalth ResEarch", Nantes university, institute of health research IRS, 44200 Nantes, France.

PMID: 29150022
DOI: 10.1016/j.therap.2017.09.002

Abstract

Aim: Poppers have become legal in France since June 2013. Is their liberalisation associated with an increase of severe side effects observed?

Methods: To identify elevated methaemoglobinaemia related to poppers abuse, we reviewed all methaemoglobin concentrations measured in Nantes university hospital, during 12 months.

Results: Methaemoglobin concentrations were superior to 25% in three cases of poppers consumption that occurred after the legalisation.

Conclusion: Evaluating the prevalence of elevated methaemoglobinaemia could help to monitor severe complications of poppers use in France.

Keywords: Abuse; Elevated methaemoglobinaemia; Poppers; Regulation.

MeSH terms

Adult
Female
France / epidemiology
Humans
Illicit Drugs / adverse effects*
Illicit Drugs / legislation & jurisprudence*
Male
Methemoglobinemia / chemically induced
Methemoglobinemia / epidemiology
Middle Aged
Vasodilator Agents / adverse effects*
Young Adult

Substances

Illicit Drugs
Vasodilator Agents