Clinical Features, Management, and Outcomes of Immune Checkpoint Inhibitor-Related Cardiotoxicity

Marion Escudier; Jennifer Cautela; Nausicaa Malissen; Yann Ancedy; Morgane Orabona; Johan Pinto; Sandrine Monestier; Jean-Jacques Grob; Ugo Scemama; Alexis Jacquier; Nathalie Lalevee; Jeremie Barraud; Michael Peyrol; Marc Laine; Laurent Bonello; Franck Paganelli; Ariel Cohen; Fabrice Barlesi; Stephane Ederhy; Franck Thuny

doi:10.1161/CIRCULATIONAHA.117.030571

Clinical Features, Management, and Outcomes of Immune Checkpoint Inhibitor-Related Cardiotoxicity

Circulation. 2017 Nov 21;136(21):2085-2087. doi: 10.1161/CIRCULATIONAHA.117.030571.

Authors

Marion Escudier^{1

2

3}, Jennifer Cautela^{1

2

3

4}, Nausicaa Malissen⁵, Yann Ancedy⁶, Morgane Orabona^{1

2

3}, Johan Pinto^{1

2

3}, Sandrine Monestier⁵, Jean-Jacques Grob⁵, Ugo Scemama⁷, Alexis Jacquier⁷, Nathalie Lalevee⁸, Jeremie Barraud^{1

2}, Michael Peyrol^{1

2}, Marc Laine^{1

2}, Laurent Bonello^{1

2

9}, Franck Paganelli^{1

2

9}, Ariel Cohen⁶, Fabrice Barlesi^{1

4

10}, Stephane Ederhy⁶, Franck Thuny^{11

3

4}

Affiliations

¹ Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Mediterranean University Cardio-Oncology Center (MEDI-CO Center), Unit of Heart Failure and Valvular Heart Diseases, Department of Cardiology, Hôpital Nord, Marseille, France (M.E., J.C., M.O., J.P., J.B., M.P., M.L., L.B., F.P., F.T.).
² Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), France (M.E., J.C., M.O., J.P., J.B., M.P., M.L., L.B., F.P., F.T.).
³ Groupe Méditerranéen de Cardio-Oncologie (gMEDICO), France (M.E., J.C., M.O., J.P., F.T.).
⁴ Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Oncosaftey Network of the Early Phases Cancer Trials Center (CLIP), Marseille, France (J.C., F.B., F.T.).
⁵ Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Department of Dermatology, Hôpital Timone, Marseille, France (N.M. S.M., J.J.G.).
⁶ Hôpitaux Universitaires Paris-Est, Hôpital Saint Antoine, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Unité mixte de recherche, INSERM 856, Université Pierre et Marie Curie (Paris VI), France (Y.A., A.C., S.E.).
⁷ Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Department of Radiology and Cardiovascular Imaging, Hopital Nord, Marseille, France (U.S., A.J.).
⁸ Aix-Marseille University, Technological Advances for Genomics and Clinics (TAGC), Unité mixte de recherche/INSERM 1090, Marseille, France (N.L.).
⁹ Aix-Marseille University, Unité mixte de recherche, INSERM 1076, Marseille, France (L.B., F.P.).
¹⁰ Aix-Marseille University, Assistance Publique-Hôpitaux de Marseille, Multidisciplinary Oncology & Therapeutic Innovations Department, Hôpital Nord, Marseille, France (F.B.).
¹¹ Mediterranean Association for Research and Studies in Cardiology (MARS Cardio), France (M.E., J.C., M.O., J.P., J.B., M.P., M.L., L.B., F.P., F.T.) [email protected].

PMID: 29158217
DOI: 10.1161/CIRCULATIONAHA.117.030571

No abstract available

Keywords: cardiotoxicity; immunotherapy; neoplasms.

Publication types

Letter
Multicenter Study

MeSH terms

Adult
Aged
Aged, 80 and over
Allergy and Immunology
Antineoplastic Agents, Immunological / adverse effects*
Cardiology
Cardiotoxicity
Databases, Factual
Female
Heart Diseases / chemically induced*
Heart Diseases / diagnosis
Heart Diseases / immunology
Heart Diseases / mortality
Humans
Male
Middle Aged
Neoplasms / drug therapy*
Neoplasms / immunology
Neoplasms / pathology
Retrospective Studies
Risk Assessment
Risk Factors
Time Factors
Young Adult

Substances

Antineoplastic Agents, Immunological