111In-DTPA-Octreotide SPECT (OctreoScan) Uptake in Metastatic Renal Cell Carcinoma to the Pancreas

Clin Nucl Med. 2018 Jan;43(1):e29-e30. doi: 10.1097/RLU.0000000000001898.

Abstract

We report a case of late presentation of metastatic renal cell carcinoma (RCC) demonstrating intense In-DTPA-octreotide uptake in pancreas without recurrence at the primary site. Immunohistochemistry study revealed somatostatin receptor subtype 2 of metastatic RCC preferentially expressed on tumor endothelial cells. The typical hypervascular features of RCC with intense homogeneous contrast enhancement in the arterial phase on CT should raise the possibility of metastatic RCC. This case illustrates that RCC can demonstrate high octreotide uptake in abdominal metastases.

Publication types

  • Case Reports

MeSH terms

  • Biological Transport
  • Carcinoma, Renal Cell / pathology*
  • Humans
  • Kidney Neoplasms / pathology*
  • Male
  • Middle Aged
  • Octreotide / analogs & derivatives*
  • Octreotide / metabolism
  • Pancreatic Neoplasms / diagnostic imaging
  • Pancreatic Neoplasms / metabolism*
  • Pancreatic Neoplasms / secondary*
  • Tomography, Emission-Computed, Single-Photon*

Substances

  • indium-111-octreotide
  • Octreotide