Swell, or Not Too Swell: Cytokines Regulate Arterial Aneurysm Formation

Peter Libby; Amélie Vromman

doi:10.1016/j.immuni.2017.11.011

Swell, or Not Too Swell: Cytokines Regulate Arterial Aneurysm Formation

Immunity. 2017 Nov 21;47(5):814-816. doi: 10.1016/j.immuni.2017.11.011.

Authors

Peter Libby¹, Amélie Vromman²

Affiliations

¹ Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: [email protected].
² Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

PMID: 29166584
DOI: 10.1016/j.immuni.2017.11.011

Abstract

Arterial remodeling participates pivotally in many diseases including arterial aneurysms. In this issue of Immunity, Da Ros et al. (2017) report that, in experimental aortic aneurysm formation, neutralization of interleukin-1β reduced arterial wall stiffness and hampered aneurysm development.

Publication types

Comment

MeSH terms

Animals
Aortic Aneurysm*
Aortic Aneurysm, Abdominal*
Cytokines
Disease Models, Animal
Interleukin-1beta
Mice
Mice, Inbred C57BL
Transforming Growth Factor beta

Substances

Cytokines
Interleukin-1beta
Transforming Growth Factor beta