On the Validity of Beer-Lambert Law and its Significance for Sunscreens

Photochem Photobiol. 2018 Mar;94(2):384-389. doi: 10.1111/php.12861. Epub 2018 Jan 11.

Abstract

The sun protection factor (SPF) is the most important quantity to characterize the performance of sunscreens. As the standard method for its determination is based on clinical trials involving irradiation of human volunteers, calculations of sunscreen performance have become quite popular to reduce the number of in vivo studies. Such simulations imply the calculation of UV transmittance of the sunscreen film using the amounts and spectroscopic properties of the UV absorbers employed, and presuppose the validity of the Beer-Lambert law. As sunscreen films on human skin can contain considerable concentrations of UV absorbers, it is questioned whether the Beer-Lambert law is still valid for these systems. The results of this work show that the validity of the Beer-Lambert law is still given at the high concentrations at which UV absorbers occur in sunscreen films on human skin.

MeSH terms

  • Absorption, Radiation
  • Adipates / chemistry
  • Benzimidazoles / chemistry
  • Humans
  • Reproducibility of Results
  • Salicylates / chemistry
  • Skin / radiation effects*
  • Sun Protection Factor / methods*
  • Sunscreening Agents / chemistry*
  • Sunscreening Agents / pharmacology
  • Ultraviolet Rays / adverse effects*
  • Water
  • ortho-Aminobenzoates / chemistry

Substances

  • Adipates
  • Benzimidazoles
  • Salicylates
  • Sunscreening Agents
  • ortho-Aminobenzoates
  • Water
  • 2-ethylhexyl salicylate
  • dibutyl adipate
  • menthyl anthranilate
  • homosalate
  • disodium phenyl dibenzimidazole tetrasulfonate