Abstract
Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 μM) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Annonaceae / chemistry
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chlorine / chemistry*
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Cyclohexenes / chemistry*
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Cyclohexenes / pharmacology*
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HeLa Cells
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Human Umbilical Vein Endothelial Cells
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Humans
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K562 Cells
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Uvaria / chemistry*
Substances
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Antineoplastic Agents, Phytogenic
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Cyclohexenes
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Chlorine