Abstract
A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD compared to all other KPD subgroups.
Keywords:
Beta cell death; Diabetic Ketoacidosis; Insulin DNA; Islet dysfunction; Ketosis prone diabetes.
Copyright © 2017. Published by Elsevier Inc.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Biomarkers / analysis
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Biomarkers / blood*
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Cohort Studies
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DNA / blood
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DNA Methylation*
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Diabetes Mellitus, Type 1 / blood*
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Diabetes Mellitus, Type 1 / diagnosis*
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Diabetes Mellitus, Type 1 / genetics
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / diagnosis
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Diabetes Mellitus, Type 2 / genetics
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Diabetic Ketoacidosis / blood
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Diabetic Ketoacidosis / diagnosis
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Diabetic Ketoacidosis / genetics
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Female
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Humans
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Insulin / blood
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Insulin / genetics*
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Insulin-Secreting Cells / physiology
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Male
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Up-Regulation / genetics