Autobiographical memory compromise in Alzheimer's disease: a cognitive and clinical overview

Geriatr Psychol Neuropsychiatr Vieil. 2017 Dec 1;15(4):443-451. doi: 10.1684/pnv.2017.0704.

Abstract

Autobiographical memory refers to memory for personal information. The compromise of autobiographical memory in Alzheimer's disease (AD) results in a loss of knowledge about events and facts that defined the patients' life, and consequently, degradation of their self-knowledge and sense of identity. The compromise of autobiographical memory in AD can be attributed to a diminished subjective experience of memory and a diminished sense of the self. Our review provides a comprehensive overview of cognitive and clinical processes that may be involved in difficulties to retrieve autobiographical memories in Alzheimer's disease. Our review also proposes a theoretical model according to which, the diminished ability to retrieve contextual information and the overgenerality of recall result in a diminished subjective experience of past and future thinking. Besides its theoretical contribution, our review proposes clinical applicability for evaluation and rehabilitation of autobiographical memory in AD.

Keywords: Alzheimer's disease; autobiographical memory; consciousness.

Publication types

  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / psychology*
  • Cognition Disorders / etiology
  • Cognition Disorders / psychology
  • Cognition*
  • Humans
  • Memory, Episodic*
  • Mental Recall
  • Middle Aged