Quantitative methods for assessing a synergistic or potentiated genotoxic response

Mutat Res. 1989 Feb;216(1):1-8. doi: 10.1016/0165-1161(89)90017-4.

Abstract

The problem of assessing chemical interactions in studies of genotoxicity is discussed. Attention is focused on assessing possible synergism or potentiation when the observed genotoxic response is binary (yes-no). Different forms of enhancement are distinguished based upon different assumptions on the genotoxic activity of the experimental treatments. A generalized linear statistical model is considered that links the probability of the binary response to the doses, and data-analytic strategies are described for detecting synergy and potentiation in factorially designed experiments. This approach is illustrated with a series of analyses of various genotoxicity data-sets.

MeSH terms

  • Aminacrine / toxicity
  • Caffeine / toxicity
  • Chromates / toxicity
  • Drug Synergism*
  • Hydroxyurea / toxicity
  • Models, Biological
  • Mutagenicity Tests / standards*
  • Potassium Compounds*
  • Statistics as Topic
  • X-Rays

Substances

  • Chromates
  • Potassium Compounds
  • Caffeine
  • potassium chromate(VI)
  • Aminacrine
  • Hydroxyurea