Incidence and prevention of infective endocarditis and bacteraemia after transcatheter aortic valve implantation in a French university hospital: a retrospective study

M Gallouche; G Barone-Rochette; P Pavese; B Bertrand; G Vanzetto; H Bouvaist; I Pierre; D Schmitt; J Fauconnier; Y Caspar; C Recule; R Picot-Guéraud; J P Stahl; M R Mallaret; C Landelle

doi:10.1016/j.jhin.2017.11.013

Incidence and prevention of infective endocarditis and bacteraemia after transcatheter aortic valve implantation in a French university hospital: a retrospective study

J Hosp Infect. 2018 May;99(1):94-97. doi: 10.1016/j.jhin.2017.11.013. Epub 2017 Nov 28.

Authors

M Gallouche¹, G Barone-Rochette², P Pavese³, B Bertrand⁴, G Vanzetto², H Bouvaist⁴, I Pierre³, D Schmitt⁵, J Fauconnier⁶, Y Caspar⁷, C Recule⁷, R Picot-Guéraud⁸, J P Stahl³, M R Mallaret⁹, C Landelle¹⁰

Affiliations

¹ Hospital Hygiene Unit, Grenoble Alpes University Hospital, Grenoble, France.
² Cardiology Unit, Grenoble Alpes University Hospital, Grenoble, France; INSERM U1039, Bioclinic Radiopharmaceutics Laboratory, Grenoble, France; French Alliance Clinical Trial, French Clinical Research Infrastructure Network, Toulouse, France.
³ Infectious Diseases Unit, Grenoble Alpes University Hospital, Grenoble, France.
⁴ Cardiology Unit, Grenoble Alpes University Hospital, Grenoble, France.
⁵ Pharmacy, Grenoble Alpes University Hospital, Grenoble, France.
⁶ Medical Information Department, Grenoble Alpes University Hospital, Grenoble, France; University Grenoble Alpes/CNRS, ThEMAS TIM-C UMR 5525, Grenoble, France.
⁷ Bacteriology Laboratory, Grenoble Alpes University Hospital, Grenoble, France.
⁸ Interhospital Network for Prevention of Nosocomial Infections, Grenoble Alpes University Hospital, Grenoble, France.
⁹ Hospital Hygiene Unit, Grenoble Alpes University Hospital, Grenoble, France; University Grenoble Alpes/CNRS, ThEMAS TIM-C UMR 5525, Grenoble, France.
¹⁰ Hospital Hygiene Unit, Grenoble Alpes University Hospital, Grenoble, France; University Grenoble Alpes/CNRS, ThEMAS TIM-C UMR 5525, Grenoble, France. Electronic address: [email protected].

PMID: 29191610
DOI: 10.1016/j.jhin.2017.11.013

Abstract

Infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is a rare but severe complication. Among 326 patients who underwent TAVI at Grenoble Alpes University Hospital, six (1.8%) cases of IE and 11 (3.4%) cases of bacteraemia were identified. No cases of IE were linked to the intervention; one was due to Staphylococcus aureus despite a screening and targeted decolonization strategy. This underscores the need for randomized studies to evaluate the benefit and cost-effectiveness of this policy.

Keywords: Bacteraemia; Decolonization; Infective endocarditis; Screening; Staphylococcus aureus; Transcatheter aortic valve implantation.

MeSH terms

Aged
Aged, 80 and over
Bacteremia / epidemiology*
Endocarditis / complications*
Endocarditis / epidemiology*
Female
France / epidemiology
Hospitals, University*
Humans
Incidence
Male
Middle Aged
Retrospective Studies
Staphylococcal Infections / epidemiology
Staphylococcus aureus / isolation & purification
Transcatheter Aortic Valve Replacement / adverse effects*