A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire

Eur J Immunol. 2018 Mar;48(3):546-548. doi: 10.1002/eji.201747267. Epub 2017 Dec 27.

Abstract

Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Recently, Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. Thus, the generation of Airefl/fl mouse strain enables the investigation of the cell-specific function of Aire.

Keywords: Aire; Conditional knockout; Immune tolerance; Medullary thymic epithelial cells.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIRE Protein
  • Animals
  • Antigen-Presenting Cells / pathology
  • Cell Lineage / genetics
  • Cell Lineage / immunology
  • Female
  • Humans
  • Immune Tolerance / genetics*
  • Male
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Polyendocrinopathies, Autoimmune / genetics*
  • Polyendocrinopathies, Autoimmune / immunology*
  • Polyendocrinopathies, Autoimmune / pathology
  • Reproduction / genetics
  • Reproduction / immunology
  • Transcription Factors / genetics*
  • Transcription Factors / immunology*

Substances

  • Transcription Factors