Peptides isolated from animal venom as a platform for new therapeutics for the treatment of Alzheimer's disease

L C Camargo; G A A Campos; P Galante; A M Biolchi; J C Gonçalves; K S Lopes; M R Mortari

doi:10.1016/j.npep.2017.11.010

Peptides isolated from animal venom as a platform for new therapeutics for the treatment of Alzheimer's disease

Neuropeptides. 2018 Feb:67:79-86. doi: 10.1016/j.npep.2017.11.010. Epub 2017 Nov 28.

Authors

L C Camargo¹, G A A Campos¹, P Galante¹, A M Biolchi¹, J C Gonçalves¹, K S Lopes¹, M R Mortari²

Affiliations

¹ Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil.
² Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasília, Brasília, Brazil. Electronic address: [email protected].

PMID: 29198480
DOI: 10.1016/j.npep.2017.11.010

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease that deeply affects patients, their family and society. Although scientists have made intense efforts in seeking the cure for AD, no drug available today is able to stop AD progression. In this context, compounds isolated from animal venom are potentially successful drugs for neuroprotection, since they selectively bind to nervous system targets. In this review, we presented different studies using peptides isolated from animal venom for the treatment of AD. This is a growing field that will be very helpful in understanding and even curing neurodegenerative diseases, especially AD.

Keywords: Alzheimer's disease; Memory; Neuroprotection; Peptides; Treatment; Venom.

Publication types

Review

MeSH terms

Alzheimer Disease / drug therapy*
Alzheimer Disease / metabolism
Amyloid beta-Peptides / metabolism*
Animals
Disease Progression
Humans
Memory / physiology*
Peptides / therapeutic use*
Venoms / metabolism*

Substances

Amyloid beta-Peptides
Peptides
Venoms