C-glycosides from the stems of Calophyllum membranaceum

Ling-Juan Zhu; Sen Yi; Xue Li; Hai-Feng Chen; Meng Ming; Xue Zhang; Xin-Sheng Yao

doi:10.1080/10286020.2017.1409734

C-glycosides from the stems of Calophyllum membranaceum

J Asian Nat Prod Res. 2018 Jan;20(1):49-54. doi: 10.1080/10286020.2017.1409734. Epub 2017 Dec 6.

Authors

Ling-Juan Zhu¹, Sen Yi¹, Xue Li¹, Hai-Feng Chen², Meng Ming^{1

3}, Xue Zhang¹, Xin-Sheng Yao^{1

4}

Affiliations

¹ a Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Traditional Chinese Materia Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China.
² b School of Pharmaceutical Sciences , Xiamen University , Xiamen 361102 , China.
³ d School of Public Health , Shenyang Medical College , Shenyang 110034 , China.
⁴ c Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy , Jinan University , Guangzhou 510632 , China.

PMID: 29210296
DOI: 10.1080/10286020.2017.1409734

Abstract

Three new C-glycosides, calophymembransides D-F (1-3), were isolated from the stems of Calophyllum membranaceum Gardn. et Champ.. The structures were assigned on the basis of spectroscopic data. RXRα transcriptional inhibition and α-glucosidase inhibition assays indicated that all the isolates were inactive.

Keywords: C-glycosides; Calophyllum membranaceum; calophymembranside D; calophymembranside E; calophymembranside F.

MeSH terms

Calophyllum / chemistry*
Glycoside Hydrolase Inhibitors / chemistry
Glycoside Hydrolase Inhibitors / isolation & purification
Glycoside Hydrolase Inhibitors / pharmacology*
Glycosides
Molecular Structure
Monosaccharides / chemistry
Monosaccharides / isolation & purification*
Plant Stems / chemistry
alpha-Glucosidases / metabolism

Substances

C-glycoside
Glycoside Hydrolase Inhibitors
Glycosides
Monosaccharides
alpha-Glucosidases