Abstract
Six individuals with protracted acute type B hepatitis were treated with recombinant alpha-A-interferon for 12 weeks. Two females eliminated the HBV completely, while 4 males did not respond. Response was preceded by a flare-up of the liver disease. It appears that responses to interferon are not higher in protracted acute type B hepatitis than in progressed chronic active hepatitis B. This assumption has to be proven in larger studies on a statistical basis.
MeSH terms
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Acute Disease
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DNA, Viral / analysis
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Female
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Hepatitis B / drug therapy*
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Hepatitis B / immunology
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Hepatitis B / microbiology
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Hepatitis B Surface Antigens / analysis
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Hepatitis B e Antigens / analysis
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Hepatitis B virus / genetics
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Hepatitis B virus / isolation & purification
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Humans
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Interferon Type I / adverse effects
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Interferon Type I / therapeutic use*
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Male
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Pilot Projects
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Recombinant Proteins
Substances
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DNA, Viral
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Hepatitis B Surface Antigens
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Hepatitis B e Antigens
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Interferon Type I
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Recombinant Proteins