PSMA brings new flavors to PI3K signaling: A role for glutamate in prostate cancer

J Exp Med. 2018 Jan 2;215(1):17-19. doi: 10.1084/jem.20172050. Epub 2017 Dec 8.

Abstract

In this issue of JEM, Kaittanis et al. (https://doi.org/10.1084/jem.20171052) report a new signaling role for prostate-specific membrane antigen (PSMA), providing a mechanistic link between two major oncogenic pathways, as well as promising therapeutic implications for the diagnosis and treatment of prostate cancer.

Publication types

  • Comment

MeSH terms

  • Antigens, Surface
  • Folic Acid
  • Glutamic Acid
  • Humans
  • Male
  • Phosphatidylinositol 3-Kinases*
  • Prostatic Neoplasms
  • Receptors, Metabotropic Glutamate*

Substances

  • Antigens, Surface
  • Receptors, Metabotropic Glutamate
  • Glutamic Acid
  • Folic Acid
  • Phosphatidylinositol 3-Kinases