Characteristics of computed tomography perfusion parameters in non-small-cell-lung-cancer and its relationship to histology, size, stage an treatment response

Clin Imaging. 2018 Jul-Aug:50:5-12. doi: 10.1016/j.clinimag.2017.12.001. Epub 2017 Dec 5.

Abstract

Objectives: To analyze computed tomography perfusion (CTP) parameters in NSCLC.

Materials and methods: Prospective study, 152 patients with NSCLC. CTP parameters were correlated with histology, stage, size and response to conventional chemotherapy/radiotherapy.

Results: Neuroendocrine tumours presented higher BV (p 0.002). Negative correlation of PMB (p 0.003) and positive of MTT (p 0.046) with T stage was found. BF showed negative correlation with size. No differences were found with the RECIST levels of response to chemotherapy/radiotherapy.

Conclusions: CTP parameters were highly variable. Neuroendocrine tumours presented higher BV and PMB values. Perfusion parameters do not differ depending on the stage and do not predict response to treatment.

Keywords: Computed tomography; Imaging biomarker; Lung; Lung cancer; Perfusion imaging.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Non-Small-Cell Lung / diagnostic imaging*
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Non-Small-Cell Lung / therapy
  • Female
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / pathology
  • Lung Neoplasms / therapy
  • Male
  • Middle Aged
  • Perfusion Imaging / methods*
  • Prospective Studies
  • Tomography, X-Ray Computed / methods*
  • Treatment Outcome