Assessment of Aversion of Acute Pain Stimulus through Conditioned Place Aversion

Louise Urien; Qiaosheng Zhang; Erik Martinez; Haocheng Zhou; Nicole Desrosier; Jahrane Dale; Jing Wang

doi:10.21769/BioProtoc.2595

Assessment of Aversion of Acute Pain Stimulus through Conditioned Place Aversion

Bio Protoc. 2017 Nov 5;7(21):e2595. doi: 10.21769/BioProtoc.2595.

Authors

Louise Urien^{1

2}, Qiaosheng Zhang^{1

2}, Erik Martinez¹, Haocheng Zhou¹, Nicole Desrosier¹, Jahrane Dale^{1

2}, Jing Wang^{1

2}

Affiliations

¹ Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, NY, USA.
² Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, USA.

Abstract

Pain is a complex experience. The aversive component of pain has been assessed through conditioned place aversion in rodents. However, this behavioral test does not allow the evaluation of the aversion of an acute pain stimulus. In Zhang et al. (2017), we provide an updated version of a Conditioned Place Aversion paradigm to address this challenge. In this protocol, a detailed version of this method is described.

Keywords: Acute pain; Conditioned Place Aversion; Laser stimulus; Optogenetic stimulation.

Abstract

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