Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes

F Bonatti; A Adorni; A Percesepe; D Martorana

doi:10.1111/iji.12351

Discrimination of FCGR2B polymorphism without coamplification of FCGR2A and FCGR2C genes

Int J Immunogenet. 2018 Feb;45(1):22-25. doi: 10.1111/iji.12351. Epub 2017 Dec 11.

Authors

F Bonatti¹, A Adorni², A Percesepe^{1

2}, D Martorana²

Affiliations

¹ Department of Medicine and Surgery, University of Parma, Parma, Italy.
² Unit of Medical Genetics, University Hospital of Parma, Parma, Italy.

PMID: 29227030
DOI: 10.1111/iji.12351

Abstract

The FCGR locus is characterized by high polymorphism and sequence homology. In particular, the Ile232Thr polymorphism in the FCGR2B gene results in inaccurate genotyping in most published papers. The purpose of the study was to develop an accurate genotyping assay able to discriminate this polymorphism.

Keywords: Fcγ receptors; autoimmune diseases susceptibility; genotyping; pharmacogenetics; single nucleotide polymorphism.

Publication types

Clinical Trial

MeSH terms

Female
Genotyping Techniques / methods*
Humans
Male
Polymorphism, Genetic*
Receptors, IgG / genetics*

Substances

FCGR2A protein, human
FCGR2B protein, human
FCGR2C protein, human
Receptors, IgG