Exposures to fine particulate matter (PM_2.5) and birthweight in a rural-urban, mother-child cohort in Tamil Nadu, India

Background: Exposure to PM_2.5 (fine particulate matter <less than 2.5µm in aerodynamic diameter) related to ambient and household air pollution has been associated with low birthweight. Few of these studies, however, have been conducted in high exposure settings that are commonly encountered in low and middle income countries (LMICs).

Objectives: We examined whether PM_2.5 exposures during pregnancy were associated with birthweight in an integrated rural-urban, mother-child cohort in the state of Tamil Nadu, India.

Methods: We recruited 1285 pregnant women in the first trimester of pregnancy from primary health care centers and urban health posts and followed them until birth to collect antenatal care data and birthweight. We estimated pregnancy period PM _2.5 exposures through direct serial measurements of 24-h household PM_2.5 concentrations, performed across each trimester. Mothers also completed detailed questionnaires to provide data on covariates related to household, socio-economic, demographic and maternal health characteristics. The association between PM_2.5 exposures and birth weight was assessed using linear and logistic regression models that controlled for potential confounders.

Results: A 10-μg/m³ increase in pregnancy period PM_2.5 exposures was associated with a 4g (95% CI: 1.08g, 6.76g) decrease in birthweight and 2% increase in prevalence of low birthweight [odds ratio(OR) = 1.02; 95%CI:1.005,1.041] after adjusting for gestational age, infant sex, maternal BMI, maternal age, history of a previous low birth weight child, birth order and season of conception.

Conclusions: The study provides some of the first quantitative effects estimates for linking rural-urban PM_2.5 exposures and birthweight in India, adding important evidence for this association from high exposure settings in LMICs, that also experience dual health burdens from ambient and household air pollution. Study results also point to the need for considering maternal PM_2.5 exposures alongside other risk factors for low birthweight in India.