Antimicrobial susceptibility of Neisseria gonorrhoeae isolates in Vientiane, Lao PDR

J Glob Antimicrob Resist. 2018 Jun:13:91-93. doi: 10.1016/j.jgar.2017.12.001. Epub 2017 Dec 8.

Abstract

Objectives: The aim of this study was to determine the antimicrobial susceptibility of Neisseria gonorrhoeae isolates in the Lao People's Democratic Republic (Laos).

Methods: A total of 165 gonococcal isolates (1.3%) were obtained from 12 281 genital samples routinely submitted to a diagnostic laboratory in Vientiane, Laos, between 2011 and 2015. Susceptibility to five antibiotics was determined by the standard disk diffusion method for 158 of the isolates.

Results: Rates of resistance to penicillin (by β-lactamase production), tetracycline and ciprofloxacin were 89.9%, 99.4% and 84.8%, respectively. All isolates were susceptible to ceftriaxone and spectinomycin.

Conclusions: The situation in Laos is similar to that in neighbouring countries; this fortunately means that the latest Lao national guidelines for treating gonorrhoea should still be effective.

Keywords: Antimicrobial resistance; Antimicrobial susceptibility; Gonorrhoea; Lao PDR; Laos; Neisseria gonorrhoeae.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology*
  • Ceftriaxone / pharmacology
  • Child
  • Child, Preschool
  • Ciprofloxacin / pharmacology
  • Drug Resistance, Multiple, Bacterial*
  • Female
  • Gonorrhea / epidemiology
  • Gonorrhea / microbiology
  • Humans
  • Laos / epidemiology
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / enzymology
  • Young Adult
  • beta-Lactamases / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Ciprofloxacin
  • Ceftriaxone
  • beta-Lactamases