Abstract
A novel and versatile design of DNA-lipid conjugates is presented. The assembly of the DNA headgroups into G-quadruplex structures is essential for the formation of micelles and their stability. By hybridization with a complementary oligonucleotide the micelles were destabilized, resulting in cargo release. In combination with a hairpin DNA aptamer as complementary strand, the release is obtained selectively by the presence of ATP.
MeSH terms
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Adenosine Triphosphate / chemistry
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Animals
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Aptamers, Nucleotide / genetics
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Carbocyanines / chemistry
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Cattle
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DNA / chemistry*
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DNA / genetics
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Drug Carriers / chemistry*
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Drug Liberation
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Fluorescent Dyes / chemistry
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G-Quadruplexes*
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Lipids / chemistry*
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Micelles
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Nucleic Acid Hybridization
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Oxazines / chemistry
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Serum Albumin, Bovine / chemistry
Substances
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Aptamers, Nucleotide
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Carbocyanines
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Drug Carriers
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Fluorescent Dyes
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Lipids
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Micelles
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Oxazines
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Serum Albumin, Bovine
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3,3'-dioctadecylindocarbocyanine
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3,3'-dioctadecyloxacarbocyanine
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Adenosine Triphosphate
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DNA
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nile red